This ScienceHub file shows the physiological data associated with the manuscript Adrenal Stress Hormone Regulation of Hepatic Homeostatic Function After an Acute Ozone Exposure in Wistar-Kyoto Male Rats published in Toxicological Sciences in 2022. These data examine how adrenalectomy modifies the response to ozone, with a specific focus on hepatic response. This dataset is associated with the following publication: Jackson, T., A. Henriquez, S. Snow , M. Schladweiler, A. Astriab Fisher, D. Alewel, J. House, and U. Kodavanti. Adrenal stress hormone regulation of hepatic homeostatic function after an acute ozone exposure in Wistar-Kyoto Male Rats. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 189(1): 73-90, (2022).