This dataset includes TIMES model files associated with generating scenarios for the paper (https://iopscience.iop.org/article/10.1088/2753-3751/ad958b). The study utilized US EPA's TIMES database version: EPAUS9rT_v20.4. The other file includes underlying data used for figures in the manuscript (FigureData_formatted.xlsx). This dataset is associated with the following publication: Zalesak, A., N. Kittner, D. Loughlin, and P. Kaplanakman. Evaluation of energy, carbon dioxide, and air emission implications of medium- and heavy-duty truck electrification in the United States using EPA’s regional TIMES energy systems model. Environmental Research: Energy. IOP Publishing, BRISTOL, UK, 1: 045018, (2024).